Harmony was developed by Antipodean Pharmaceuticals in the mid '40s, and was in the testing phase at the time of the '48 Crash. As the research laboratories  were located in the Blue Mountains, the company survived the tsunami, but not the economic fallout and shut its doors for the last time on the 11th of November, 2049. By then, the negative side effects had begun to present  themselves, forcing the closure of the project. The drug was never comprehensively studied and little is known of its long term effects. 

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